This issue is a variant of The Amazing Spider-Man (Marvel, 1999 series) #527 [Newsstand Edition]. There exist further variants.
All 12 issues of "The Other" storyline running through the Spider-Man books have a variant cover by Wieringo and Kesel depicting Spidey swinging through Doc Ock's arms and exploding pumpkin bombs wearing a different costume in each cover.
Recap of the events which led to the start of this issue with credits and indicia.
"The Other: Evolve Or Die" Part 9 of 12. Story continued from MARVEL KNIGHTS SPIDER-MAN (Marvel, 2004 series) #21. Story continues in FRIENDLY NEIGHBORHOOD SPIDER-MAN (Marvel, 2005 series) #4.
Checklist of upcoming parts 10 to 12 of "The Other" storyline with previews of cover art.
Total of 10 one-page advertisements for: Gauntlet: Seven Sorrows (game, Midway), Kameo: Elements of Power (game, Microsoft), Genji: Dawn of the Samurai (game, Sony), Jak X: Combat Racing (game, Sony), The Excorcism of Emily Rose (dvd, Tower Records), Pressure (anti-drugs, Office of National Drug Control), Stereotype (anti-drugs, Office of National Drug Control), Hey True Believers! (Marvel VIP retailers, comics retailers), X-Men Legends II: Rise of Apocalypse (game, ActiVision), Perfect Dark Zero (game, Microsoft)