This issue is a variant of The Amazing Spider-Man (Marvel, 1999 series) #525 [Newsstand Edition]. There exist further variants.
Recap of the events which led to the start of this issue with credits and indicia.
"The Other: Evolve Or Die" Part 3 of 12. Story continued from MARVEL KNIGHTS SPIDER-MAN #19 (Marvel, 2004 series). Story continues in FRIENDLY NEIGHBORHOOD SPIDER-MAN #2 (Marvel, 2005 series).
Average no. copies each issue during preceding 12 months: 103,377.