This issue is a variant of The Amazing Spider-Man (Marvel, 1999 series) #525 [Newsstand Edition]. There exist further variants.
Recap of the events which led to the start of this issue with credits and indicia.
"The Other: Evolve Or Die" Part 3 of 12. Story continued from MARVEL KNIGHTS SPIDER-MAN #19 (Marvel, 2004 series). Story continues in FRIENDLY NEIGHBORHOOD SPIDER-MAN #2 (Marvel, 2005 series).
Checklist of upcoming parts 4 to 6 of "The Other" storyline with previews of cover art.
House Advertisement for: THE THING series (2/3 page).
Average no. copies each issue during preceding 12 months: 103,377.
Total of 20 one-page and 3 two-page advertisements for: milk (milk, whymilk.com), Honda Civic (car, Honda, 2 pages), NKE6.com (shoes, Nike), The Fog (movie, Columbia), Drink More Dew (Mountain Dew, PepsiCo), X-Men Legends II: Rise of Apocalypse (game, ActiVision), House of Wax (dvd, WB), Vintage Rock Shirts (t-shirts, Anthill Trading), Marvel Nemesis (game, EA, 2 pages), The Legend of Zorro (movie, Columbia), Pirates! Live the Life (game, 2K Games), Fable: The Lost Chapters (game, Microsoft), Midtown Comics (comic shop, Midtown Comics), Age of Empires III (game, Microsoft, 2 pages), Lords of Dogtown (dvd, Sony), He-Man and the Masters of the Universe Season One (dvd, Entertainment Rights), FragBox (computer hardware, NVIDIA), Star Wars Battlefront II (game, Lucas Arts), Count Duckula Complete First Seeson (dvd, Capitalent), Elektra Director's Cut (dvd, Regency), Batman Begins (movie, WB), Gauntlet: Seven Sorrows (game, Midway), Skechers (shoes, Skechers).