This issue is a variant of The Amazing Spider-Man (Marvel, 1999 series) #526 [Newsstand Edition]. There exist further variants.
Recap of the events which led to the start of this issue with credits and indicia.
"The Other: Evolve Or Die" Part 6 of 12. Story continued from MARVEL KNIGHTS SPIDER-MAN #20 (Marvel, 2004 series). Story continues in FRIENDLY NEIGHBORHOOD SPIDER-MAN #3 (Marvel, 2005 series).
Checklist of upcoming parts 7 to 9 of "The Other" storyline with previews of cover art.
House Advertisements for: DECIMATION event incl. Checklist
Total of 18 one-page and 2 two-page advertisements for: Kameo: Elements of Power (game, Microsoft), Fire Emblem: Path of Radiance (game, Nintendo), Ringers: Lord of the Fans (dvd, Sony), Matrix: Path of Neo (game, Atari), Age of Empires III (game, Ensemble Studios, 2 pages), Genji: Dawn of the Samurai (game, Sony, 2 pages), Fantastic Four (dvd, 20th Century Fox), X-Men Legends II: Rise of Apocalypse (game, ActiVision), What Do You Play In? (apparel, purehero.com), Shadow of the Colossus (game, Sony, 2 pages), Perfect Dark Zero (game, Microsoft), Midtown Comics (comic shop, Midtown Comics), www.until.org (HIV website, until.org), Batman Begins (dvd, WB), Masters of Horror (tv, Showtime), Dragonball Z: Budokai Tenkaichi (game, Atari), NKE6.com (shoes, Nike), Tony Hawk's American Wasteland (game, ActiVision), Aeon Flux (movie, Paramount).