Spider-Man [also appears as Peter Parker]; Jonah Jameson; Betty Brant; Joe Robertson; Dexter Bennett; Bill Hollister; Lily Hollister; May Parker; Freak; Vin Gonzales [Charles Vincent Gonzales]; Al O'Neill; Harry Osborn; Carlie Cooper; Bookie; Black Mamba; Speed Demon; Slyde; Wrecker; Spot; Trapster; Thunderball; Lightmaster; Bulldozer; Shriek; Doctor Bong; Ox
Synopsis
The Daily Bugle spreads the story that Spider-Man is a serial killer. A drug addict nicknamed Freak steals an experimental formula, mistaking it for meth, and undergoes a horrible mutation.
letters submitted by Jeff Ghearing; Brian Cahill; Greg Delaney; Angela Bullock; Josh Rector; page also includes cover art for the following issue (#553)