This issue has variants.
This issue introduced Sabrina the Teen-Age witch, created by Dan DeCarlo and George Gladir. She would make intermittent appearances in "Mad House" throughout the decade, finally getting her own comic in the early '70s after Filmation turned her into a Saturday morning cartoon.
First appearance of Sabrina, her cat Salem, and Della the Head Witch.
Much of this early version of Sabrina appears to be based on the play "Bell, Book and Candle" and the film version, starring Kim Novak. The rule about witches losing their powers if they fall in love and the inability of witches to cry (both of which were dropped in subsequent versions of Sabrina) were used in "Bell, Book and Candle," and Sabrina's cat Salem is similar to Pyewacket, the witch's familiar in "Bell, Book and Candle."
In the COMICS v10 #5 G. Gladir states that Sabrina was named after a woman he remembered from his teens who he later found out was actually named Sabra not Sabrina. He also states that he wrote all Sabrina and Hilda stories until Sabrina went to Saturday morning animation in 1969.