G.I. Joe [Hawk; Duke; Snake-Eyes; Scarlett; Flint; Roadblock; Shipwreck; Stalker; Gung-Ho; Wild Bill; Lady Jaye; Dusty; Mainframe; Rock 'N Roll; Jinx; Spirit Iron-Knife; Lifeline; Kamakura; Daemon (1st appearance); Firewall (1st appearance)]; William Kessler [Billy] (guest star); Cobra Commander (villain); Destro I (villain); Destro II (villain); Baroness (villain); Major Bludd (villain); Mistress Armada (villain); Zartan (villain); Buzzer (villain); Thrasher (villain); Dreadnoks (villains); Zanya (villain); Iron Grenadiers (villains); Cobra Soldiers (villains); Tele-Vipers (villains)
Synopsis
Many of the Joes are infected with nano-mites. Snake-Eyes and Scarlett escape Destro's clutches. Destro Jr. gets ready to activate the nano-mites and take over America.