The Flash [Barry Allen]; Gorilla Grodd; Darok; Iris West Allen; Solovar; Ronnie Balter; Nohra; Captain Cold (cameo); Mr. Element (cameo); Trickster [James Jesse] (cameo); Weather Wizard (cameo); Reverse Flash (cameo); Abra Kadabra (cameo); Mirror Master [Sam Scudder] (cameo); The Top (cameo); Heat Wave (cameo); Captain Boomerang [Digger Harkness] (cameo); Pied Piper (cameo)
Grodd's plan for revenge against the Scarlet Speedster involves using Iris Allen to help create and nurture a hybrid human-gorilla clone, Darok. But when Darok realizes that Grodd doesn't love him as a son and that Grodd's inclusion of a bit of the Flash's DNA is causing him to rapidly age, he works with the only person who has shown him love, Iris, to betray his maker Grodd.
Superman; The Flash [Barry Allen]; Legion of Super-Heroes [Superboy; Brainiac 5; Wildfire; Mon-El; Cosmic Boy; Princess Projectra]; Reverse-Flash [Professor Zoom]; Iylar; a Zelkot; a Volkir
In the 25th century, Superman secretly helps Flash deal with Professor Zoom, before the two head off again across time after Iylar, who is trying to reach the past and end an alien civil war before it began. Flash wants to make sure Iylar makes it through time, so that the Zelkot do not destroy Earth. Superman wants to ensure the war begins so that the Volkir visit Earth in the past and seed life on it. After a number of stops across time, Superman and Flash catch up to Iylar, stop him from preventing the war, and neutralize the aliens' threat against the Earth in the present.