There is a 2nd printing of this cover with the exact same cover image but instead of a Deadpool smiley face in DP's word balloon, he is saying, "See, Spidey? Everything was better in 1992" (the joke, of course, being that Spidey is outfitted in Cable's excessive guns, belts and pouches circa 1992).
Spider-Man; GUESTS: Deadpool; Madame Web; VILLAINS: Lady Stilt-Man; Kraven [Ana Kravinoff]; Sasha Nikolaevich; CAMEOS: J. Jonah Jameson; Michele Gonzales; Arana; Eddie Brock [Anti-Venom]; Spider-Woman [Mattie Franklin]; Prostitutes dressed as Emma Frost; Mystique; Elektra; Madame Masque; Enchantress; Black Cat; Spider-Woman; Viper; Clea
Spider-Man takes on Lady Stilt-Man. He gets a little assistance from Deadpool but soon discovers that Deadpool has merely saved him from Lady Stilt-Man so that he can dispose of him himself. Deadpool has been hired by Ana Kravinoff and her mother to kill Spidey and their fast and furious battle ends in a deadly serious game of "the dozens." Deadpool is called off by kid Kraven and leaves a very confused Spidey wondering what the heck just happened. What the heck just happened is that Deadpool was a diversion so that Ana could attack and capture Mattie Franklin, without any interference.