As with the other EC comics edited by Al Feldstein, the stories in this comic were primarily based on publisher William Gaines reading a large number of horror stories and using them to develop "springboards" from which he and Feldstein could launch new stories.
After their unauthorized adaptation of one of Ray Bradbury's stories in another magazine, Bradbury contacted EC about their plagiarism of his work. They reached an agreement for EC to do authorized versions of Bradbury's short fiction.
The Crypt-Keeper was the primary host of Tales from the Crypt. He was introduced to the public in Crime Patrol #15, and he continued with that magazine through its changes in title and format.