Black Tom is dying from his wooden infection and Banshee has Dr. Killebrew, a specialist in cellular regeneration, treat him in prison. Juggernaut breaks in, rescues Tom and captures Killebrew. Deadpool is out for a quiet drink when he is assaulted by Black Tom's goons but he gets a timely assist from old pal Banshee and his daughter, Siryn. During the battle, Deadpool's hand is cut off and he blacks out as his healing factor fails to regenerate it.
Black Tom sends Juggernaut to bring in Deadpool so that Killebrew can use the merc's regenerative powers to heal Tom's condition. Pool and Siryn get caught between Juggernaut and Daniel Peyer of Interpol.
Deadpool and Siryn battle both Juggernaut and Interpol agent, Daniel Peyer. Banshee discovers that his old pal Peyer has been lying to him and is out for revenge against Deadpool. Killebrew attaches Deadpool's severed hand to Black Tom in hopes of curing him of his condition.
Deadpool, Siryn and Banshee battle Juggernaut and Black Tom, who has been fitted with Pool's severed hand. As Killebrew's solution to Tom's condition takes a turn for the worse, the heroes and villains cease hostilities as Black Tom is taken in for medical help by Banshee. Deadpool makes off with Killebrew, the man who created him for Weapon X, so the good doctor can find out why his healing factor is failing.