Fantastic Four [Thing; Mr. Fantastic; Human Torch; Invisible Woman]; Iron Fist; Yu-Ti [Sparrow]; Dr. Strange; Jessica Jones; Pei; Danielle Cage; Avengers [Iron Man; Captain America; Captain Marvel [Carol Danvers]; Black Panther]; League of International Magic Practitioners [Señor Magico; Nana Marefa; Sorcha; Night Witch; Bob Jennings; Mr. Je-Ju]; Luke Cage; Elektra; Punisher; Black Tarantula; White Tiger [Ava Ayala]; Moon Knight; The Urchin; Wrecking Crew [Thunderball; Piledriver; Bulldozer] (cameo)
Several heroes have fallen victim to the disease, and their essences appear to have been absorbed by the Urchin, the being causing the epidemic. More heroes arrive to take their place, but the situation appears more and more hopeless.