After assisting a revolution in Bolivia (and getting paid in revolutionary bucks), Deadpool heads back to merc central to have words with Patch. Pool's next mission takes him to Antarctica to tangle with Sasquatch and blow up a gamma research station in the process. Finding out that the melting gamma core will irradiate the entire southern hemisphere, Deadpool fixes the problem and saves the day. DP is approached by Zoe and Noah and offered a position with Landau, Luckman and Lake but he quickly turns them down as being a good guy isn't exactly his style.
While Deadpool is peeping in on Siryn, a band on ninjas is capturing Weasel. Deadpool tracks down his buddy which brings him to a compound in the Nevada desert where Taskmaster is training his pupils. Being quickly taken down by Taskmaster, Pool discovers that the bad guy has offered Weasel a job working for his organization. Changing up his tactics to throw off Taskmaster's powers, DP takes down the villain but not before having his middle finger cut off.
Deadpool; Siryn; Blind Al; Doctor Killebrew; C.W.; Weasel; T-Ray; Patch
In trying to grow his middle finger back in front of his merc buddies, Deadpool is deeply embarrassed when he finds out that he can't do it. Black Tom taunts Pool by sending him the glove from the hand he removed (in the 2nd Deadpool limited series) and Deadpool collects Siryn so the two can head off to take down her evil uncle. Instead they find Killebrew, one of the doctors who created Deadpool for Weapon X, and he explains that Pool's faulty healing factor is due to the fact that he is dying.
Deadpool; Siryn; Dr. Killebrew; Hulk [Bruce Banner]
In order for Killebrew to create a cure for Deadpool's condition, Pool needs to get a sample of blood from the Hulk. The Hulk turns out not to be too fond of this idea and the fight is on. Deadpool is successful, however, and Killebrew injects him with a serum that should restore the merc with a mouth back to a healthy condition.
Deadpool; Siryn; Dr. Killebrew; Weasel; C. F.; Patch; T-Ray (Villain)
With Wade cured of his debilitating condition, he is set on killing his healer and old tormentor, Killebrew, for crimes the doctor perpetrated on him in his days with the Weapon X project, but Siryn stands in the way. T-Ray continues contract killing while plotting revenge on Deadpool.