With his bid for becoming an X-Man a total bust, Deadpool arrives in New York to learn how to be a real super hero from one of the best--Spider-Man. When mysterious assassinations begin to take place around the city, Spidey figures Deadpool is responsible and attacks him. The real culprit, however, is revealed to be Hit-Monkey, the deadliest simian on the planet, and Spidey figures that Deadpool may just be his next target.