Miguel O'Hara, hot-shot geneticist, tries to quit his job at Alchemax but is addicted to a drug by his boss, Tyler Stone. In an effort to free himself of the addiction, his genetic code is merged with a spider's genetic code.
Spider-Man 2099 [Miguel O'Hara] (origin); Venture; Gabriel O'Hara
Miguel learns about his new powers as he escapes Alchemax. Tyler Stone sends Venture, a professional tracker, after whoever was in the lab. Rather than let Venture find out who he is, Miguel dresses up and attacks him as Spider-Man.