Issues, up to #155, had two versions with different looking Big Boy characters. The "West Coast" version of Big Boy is the version that was previous created for the original franchise--black hair, red and white checkered overalls, and no hat. The "East Coast" version had Red hair, a little thinner usually, red and white striped overalls, and a cook's hat.
Starting with issue #156, the "East Coast" version no longer existed in the comics, and the "West Coast" version remained, with one subtle change, his hair was now brown instead of black.
Known possible franchise co-branded variations (printed with franchise logo [or not] and region sold):
Abdow’s (Known printed-Massachuetts, Connecticut).
Azar's (Known printed-Colorado, Northern Indiana).
Bob's (Known printed-Arizona, California, Delaware, Eastern Pennsylvania, Hawaii, New Jersey, Southeastern United States after Shoney's left the national chain to start their own).
Eat 'n Park-(Possibly printed-Pittsburgh-area 1950s).
Elby's (Known printed-Eastern Ohio, Pennsylvania, West Virginia).
Elias Brothers (Known printed-Michigan, Northwestern Ohio, Ontario (Canada)).
Franklin’s (Hand stamped. Printed as "Your Favorite Family Restaurants" issue #260 onward?-Northeastern Pennsylvania).
Frisch’s (Known printed-Kentucky, Northern Tennessee, Southern Indiana, Southern Ohio).
JB's (Known printed-Idaho, Montana, North Dakota, Rhode Island, Utah, Wyoming).
Kip's (Known printed-Kansas, Oklahoma, Texas).
Lendy’s Yoda's (Hand stamped, pre-1961 was part of the Shoney's chain-Virginia).
Manner’s (Known printed-Northeastern Ohio).
Marc’s (Known printed-Iowa, Minnesota, Wisconsin).
McDowell's (Printed as "Your Favorite Family Restaurants" issue #260 onward?-South Dakota).
Shoneys (Known printed-Southeastern United States.: North Carolina, South Carolina, Southern Tennessee, Virginia. Shoney's eventually left the main chain to form their own in order to branch out from the business from franchisee limitations).
TJ's (Known printed-New York).
Top's (Known printed-Illinois, perhaps Southern Wisconsin).
VIP’s (Printed as "Your Favorite Family Restaurants" issue #260 onward?-Washington, New Mexico).
Known west: Abdow's; Bob's; Azar's; Eat 'n Park; Elias Brothers; JB's; Kips; Lendy's; Shoney's; Tops.
Known East: Azar's (as of 1962); Frisch's; Manners.
Lendy's co-branding version seems to be blank where resturaunt info was printed and hand-stamped with Lakeside Yoda's (Lendy's) stamp. Implies possible blank back cover variations where co-branding does not exist for some locations or use of "Your Favorite Family Restaurants" instead?
There is a known version which the co-branding is replaced by ads, one known for the Bozo the Clown TV show on a "Channel 8" in issue #183 (area unknown).
Elias Brothers variation known to have stopped between issue #374 and 379--any others?
Towards end, back page becomes a menu, possible different franchises may have had different menus. "EL-US" code on back on menu might refer to Elias Brothers menu variant.